• Lanabecestat (AZD3293): Cell Assay Guide

  2026-09-03

  A scenario-based guide to using Lanabecestat (AZD3293), SKU BA8438, in neuronal, viability, proliferation, and cytotoxicity workflows. It connects product specifications with peer-reviewed evidence on partial BACE1 inhibition, amyloid-beta reduction, and synaptic-function interpretation.

• Reversine for Aurora Kinase Assays

  2026-09-02

  Reversine is a cell-permeable Aurora kinase inhibitor for dissecting mitotic checkpoint failure, cancer cell proliferation inhibition, and apoptosis induction in cancer cells. This practical guide connects dose–response workflows with cervical cancer research and emerging single-structure phenotyping platforms.

• nor-Binaltorphimine Dihydrochloride in Pain Circuits

  2026-09-02

  Explore how nor-Binaltorphimine dihydrochloride can convert κ-opioid receptor blockade into a precise assay variable for studying mechanical allodynia. This article translates a brain-to-spinal circuit study into practical decisions about spatial targeting, behavioral timing, controls, and compound handling.

• EZ Cap™ Firefly Luciferase mRNA: Assay Guide

  2026-09-01

  A scenario-based guide to improving reporter-based viability, proliferation, and cytotoxicity workflows with EZ Cap™ Firefly Luciferase mRNA (5-moUTP), SKU R1013. It explains assay design, handling, normalization, delivery variables, and practical criteria for selecting a reliable modified mRNA reagent.

• Partial BACE Inhibition Preserves Synaptic Function

  2026-08-31

  Satir et al. show that moderate β-secretase inhibition can reduce amyloid-β secretion by up to 50% without impairing synaptic transmission in primary rat cortical neurons. The study identifies a functional exposure window that separates potentially useful BACE target engagement from synaptic dysfunction caused by stronger inhibition.

• LAMP1 and CXCL10–CXCR3 Macrophage Polarization

  2026-08-31

  The 2024 International Immunopharmacology study identifies LAMP1 as a context-dependent molecular switch linking the CXCL10–CXCR3 axis with macrophage polarization and autophagy. Its use of AMG 487 shows that CXCR3 blockade can produce opposite macrophage outcomes in non-inflammatory versus poly(I:C)-stimulated settings and reduce acute lung injury in mice.

• β-Amanitin: A Mechanistic Assay Control

  2026-08-30

  β-Amanitin is more than a transcription inhibitor: it can serve as a mechanistic control for connecting RNA polymerase II biology with amatoxin detection research. This article explains how to use beta-amanitin thoughtfully in functional assays, interpret inhibition kinetics, and complement immunochemical workflows.

• BODIPY 581/591 C11 for Lipid Peroxidation

  2026-08-29

  BODIPY 581/591 C11 is a ratiometric fluorescent probe for monitoring lipid peroxidation in membranes and live cells. Its oxidation-linked red-to-green spectral shift supports comparative oxidative stress measurement and antioxidant capacity evaluation, but it is not a universal reactive oxygen species detector.

• Losmapimod: Practical p38 MAPK Assay Workflows

  2026-08-29

  Losmapimod and GW856553X provide a practical way to interrogate p38α/β-driven inflammation signaling modulation across biochemical, cellular, vascular, and disease-relevant models. This guide separates direct kinase inhibition from possible phosphatase-coupled effects, with workflows for vascular function improvement, hypertension research, and chronic obstructive pulmonary disease (COPD) research.

• Reserpine (N1867): Practical Lab Workflow Guide

  2026-08-28

  Reserpine (SKU N1867) is a high-purity research compound for controlled neurotransmitter depletion research, antihypertensive mechanism studies, and neuropharmacology research. This guide addresses identity confirmation, solvent selection, storage, solution preparation, and QC while defining why the material should not be used for diagnostic, therapeutic, or medical applications.

• 10 mM dNTP mixture: reliable assay workflows

  2026-08-28

  Learn how SKU K1041 supports consistent PCR, qPCR, sequencing, and DNA-based normalization within cell viability, proliferation, and cytotoxicity workflows. This scenario-driven guide separates what a 10 mM dNTP mixture can improve from variables that require independent control, including transfection conditions, cell state, and assay timing.

• BRCAness and Olaparib Sensitivity in Mesothelioma

  2026-08-27

  Borchert et al. linked homologous recombination repair defects, BAP1 mutation, and olaparib response in malignant pleural mesothelioma models. Their integrated cell-line and clinical gene-expression strategy suggests that broader BRCAness signatures may help identify tumors vulnerable to PARP inhibition, particularly alongside cisplatin.

• Weight Loss Restores Intestinal Stretch Signaling

  2026-08-27

  The reference study shows that intestinal stretch is an acute regulator of food intake and glucose tolerance, and that obesity weakens this response. Dietary and surgical weight loss restored stretch-induced satiety and nucleus of the solitary tract activation, revealing a mechanical gut–brain pathway that operates independently of tested GLP-1 signaling mechanisms.

• ARCA Cy3 EGFP mRNA (5-moUTP) Workflow

  2026-08-26

  ARCA Cy3 EGFP mRNA (5-moUTP) combines direct Cy3 tracking with EGFP translation, allowing researchers to separate cellular uptake from productive cytosolic delivery. This dual-readout format supports mRNA transfection in mammalian cells, carrier benchmarking, and intracellular localization assays without secondary RNA staining.

• MLN4924 Workflow for Neddylation Research

  2026-08-26

  MLN4924 provides a pathway-level way to test how NAE activity controls CRL-dependent protein turnover, cell-cycle stress, and cancer-cell survival. This workflow connects biochemical validation with the FBXW7-SPT6-ΔNp63 axis in esophageal cancer models while emphasizing dose, timing, and interpretation controls.

453 records 6/31 page Previous Next First page 上5页 678910 下5页 Last page